The winter enzyme family plays a very important role in mediating apoptosis. The detection can well monitor the early apoptosis of tumor cells, and evaluate the efficacy of tumor chemotherapy, which provides a reference for subsequent treatment. MRI is a non-radiative, non-invasive imaging technique with many imaging parameters, fast scanning speed and high tissue resolution. It is a common imaging method. Magnetic nanoparticles have been widely used in bioimaging. Large magnetic nanoparticles are superior to magnetic resonance imaging nanoparticles currently used in magnetic resonance imaging, but the former is quickly cleared in the blood, leading to tissue The magnetic resonance signal is lowered.
In order to solve this problem, Professor Liang Gaolin's research group designed a "smart" small molecule - triiron tetroxide composite nanoparticle, which is controlled by caspase in apoptotic tumor cells. The self-aggregation of large-sized magnetic nanoparticles can significantly enhance the transverse magnetic resonance imaging signals of tumors. They collaborated with the Zhongkai research group to perform magnetic resonance imaging of mouse tumors in the magnetic field strength of 9.4 Tesla in the Center of Strong Magnetic Science of the Chinese Academy of Sciences. The results show that the laterally weighted magnetic resonance imaging signals of the "smart" ferroferric oxide magnetic nanoparticles are significantly enhanced compared to the control group of ferroferric oxide magnetic nanoparticles, and are not toxic to mice.
Experts say that this new type of magnetic resonance nano-contrast agent can more easily, accurately and sensitively determine the activity of caspase in vitro and in vivo, thus providing a new method for the evaluation of tumor chemotherapy efficacy.
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