Chinese scientists successfully applied human placental stem cells to improve rat "diabetic foot"
September 06, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Some diabetic patients have "diabetic feet" due to poor blood flow to the limbs. To determine if stem cell treatment can help prevent or improve this situation, researchers from China conducted a study that found that they would be obtained from human placenta. Transplantation of mesenchymal stem cells into a diabetic rat model can affect blood vessel growth, improve blood flow, and help prevent severe limb ischemia (CLI) that can lead to diabetic foot, a more severe patient who may face amputation.
According to the researchers, the human placenta comes from a full-term cesarean section woman who has signed an informed letter. The use of human-derived cells has also been approved by the Ethics Committee.
After injecting stem cells into CLI-successful rats, the researchers tracked and counted stem cells at different time points. They found that the number of stem cells decreased significantly over a period of time, but a small number of cells still differentiated into blood vessels. Cells, injected stem cells also secrete cytokines. "We believe that cytokines secreted by mesenchymal stem cells can attract endothelial cells that make up the blood vessel wall. These cells can participate in the construction of new blood vessels and inhibit inflammation."
The researchers summarized their experimental data and suggested that mesenchymal stem cells can improve the ischemic condition of diabetic rats through direct cell differentiation and paracrine mechanisms, and the paracrine mechanism of stem cells may play a greater role than direct cell differentiation. .
"So far, mesenchymal stem cell therapy represents a simple, safe and effective treatment that is expected to be used in the treatment of diabetes and its related diseases. Our research provides a basis for clinical transformation based on basic experiments." To sum up.
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