First, the host name and purpose:
1 , Equipment: GMP pilot type peptide synthesizer
2 , Quantity: 1 set
3 , Description of use: for the synthesis of peptides and solid phase synthesis of small molecular organics.
Second, the main technical performance indicators and requirements, configuration:
1. Equipment motor system: The motor can ensure that the reactor speed can be adjusted steplessly, and it is not less than 800 times per minute or 100 degrees of rotation at 180 degrees (ensure the sufficiency of vortex, rotation and nitrogen blowing reaction mode to match the high Coupling synthesis)
2 , Material of the reactor and quantity: transparent polypropylene or Teflon material, a 40ml, 100ml, 200ml, 500ml each 1;
3 , Reactor use: easy to disassemble (convenient for cleaning, weighing, etc.); reactor is safe and explosion-proof, good visibility (easy to observe)
4 , amino acid input: infinite loop input, not less than 8 digits, customers can add various groups in the peptide chain, such as unnatural amino acids, special amino acids, isotope markers, etc., the number is not limited.
5 , at the same time with two amino acid addition methods: liquid phase addition and solid phase addition, no matter which method, can ensure that the fresh amino acid does not degrade, liquid amino acid residence time at room temperature does not exceed 48 hours.
6 , solvent input position: not less than 8 , of which 500ml × 5 (or more),
7 , Solvent addition method: Fully automatic addition of constant pressure flow rate reagents (user can pre-set the required amount of each coupled reagent on the computer without human-assisted operation). High precision, no measurement blind zone, reasonable pipeline design without cross-contamination.
8 , Consumables: Common consumables are used in the laboratory, such as filter membrane (material can be used for ultrasonic cleaning, repeated use), amino acid storage tanks, etc.
9 , Solvent automatic circulation device: no less than 2 sets, no need for human operation, the washing solvent is automatically separated for recycling, saving solvent.
6 , Fully enclosed design: The reaction unit is in a closed environment, the liquid transfer line is sealed, and the reaction is carried out in a closed reactor.
7 , Operating system: Fully automatic computer program control synthesis based on Windows XP platform, amino acid addition mode, reaction bottle rotation speed, reaction time, etc. can be set independently on the computer, and the whole process of synthesis is automatically controlled by computer.
8 , Password protected: Only authorized persons can modify the program or operate the instrument.
9 , With automatic recording function: each step of the whole process of synthesis can be automatically recorded and automatically saved in the database for easy reference and comparison.
Third, the synthesis process requirements:
1 , Synthesis amount: 0.25 mM-10 mM ;
2 , Synthesis method: Fmoc/t-Boc solid phase synthesis;
3 , Mixed mode: mechanical flip mixing mode ( 180 degrees 270 degrees optional); vortex vibration mode (no less than 800 vibrations per minute ) or nitrogen blowing method, the reaction is completely dead angle, resin is not damaged;
4 , Reaction time: the average coupling time per amino acid is 30 to 120 minutes : the time can be set autonomously on the computer program;
5 , Reaction efficiency: coupling rate is not less than 98%
Fourth, the installation environment:
1 , Power supply: 220V 50Hz, or 110V 60Hz ;
2 , Synthesis of claim workshop area greater than 4 m × 5 m cleanliness requirements than 100,000;
3 , The computer that controls the instrument can be placed in a separate room adjacent to the instrument, or it can be placed in the same room as the instrument;
4 , High purity nitrogen source ( 99.999 %), pressure greater than 100 psi ;
5 , The nitrogen head can be connected to a 1/2 inch outer diameter pipe;
6 , The laboratory should be equipped with ventilation, air conditioning, and bright lighting;
7 , The laboratory floor should be resistant to chemical corrosion;
8 , It is best to directly adjust the temperature and humidity in the room;
9 , measuring cylinder;
10 , magnetic stirrer and Teflon stirrer;
11 , electronic balance (accuracy up to 1mg );
12 , printer;
13 , other laboratory routine glassware, etc.;
14. Analyze the required amino acids and reagents.
5. After-sales service requirements
1. Instrument warranty: Not less than 1 year, if the accessories in the warranty are replaced, the accessories will be added for one year from the date of replacement. The supplier maintains the life after-sales service in the domestic after-sales department.
2. Provide training in peptide synthesis: the experimental site is in a user-specified laboratory;
3. Instrument manual and circuit diagram: Provide detailed instruction manual for the peptide synthesizer, circuit diagram and liquid road diagram, and provide relevant training to facilitate customer self-maintenance;
Six, the manufacturer requirements
1 , The equipment to be invested must be imported equipment: original imported;
2 , It has a larger-scale production type and adopts the same process as the bidding equipment, linear amplification.
3. Equipped with local installation engineers and after-sales maintenance personnel.Efficacy: The Institute was rigorously tested perfume lotus functions are as follows (data from the network and quality control) in the perfume lotus rich in plant placenta (pituitary hormones regulate the body, the body can maintain long-term young state) is rich in collagen and crude protein (blood pressure, circulation)
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Companies registered capital of 35 million yuan, the end of 2014 the total assets of 48.69 million yuan, including fixed assets of 37.52 million yuan. The company's existing cooperation Orange cultivation base 7043.5 acres, the company production base is located in Jiangxi County Tech Industrial Park Chu Tan industrial area, covers an area of 120 acres, it has built a standard plant 9,000 square meters, Nissan 6000 kg Orange enzymes and other liquid enzyme products. Enzyme, known as enzyme, refers to a polymer substance having biocatalytic functionality. In the catalytic reaction system an enzyme, the reactant molecules are known as substrates, enzyme substrates by catalytic conversion to another molecule. Almost all cellular activity of enzymes involved in the process are required to improve efficiency. Similar to other non-biological catalysts, enzymes chemical reactions by lowering the activation energy to accelerate the rate of the reaction, most of the enzyme catalyzed reaction rate can be increased a million times; in fact, the enzyme is to provide an activation energy needs than another low way, so that more particles to have less than the activation energy of the reaction kinetic energy, thus speeding up the reaction rate. Enzyme as a catalyst, in itself is not consumed during the reaction, it does not affect the chemical equilibrium reactions. Positive enzyme catalysis, but also a negative catalytic effect, not only to accelerate the reaction rate, but also to reduce the reaction rate. And other non-living catalysts is different, having a high degree of specificity of enzyme, only a catalytic reaction or produce a particular specific configuration.
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Ganzhou Green days Biochemical Technology Co., Ltd. , https://www.tlqcjs.com