Release date: 2007-12-07
Hepatitis B virus large protein has important significance for monitoring the antiviral treatment effect of patients. The key laboratory of Viral Infectious Diseases of the Ministry of Health, Chen Xiaoming and Yang Meifang, Institute of Infectious Diseases, First Hospital of Zhejiang University Medical College, showed that: Hepatitis B virus large protein It is of great significance for monitoring the effect of antiviral therapy in patients. The research results "Changes in Hepatitis B Virus Large Protein and DNA in Antiviral Therapy" was published in the July 2007 issue of Chinese Journal of Infectious Diseases. A total of 117 sera of lamivudine antiviral therapy patients were observed in the study, including 33 1-5 months, 47 6-10 months, 19 11-15 months, > 15 months 18 The study found that with the increase of treatment time, hepatitis B virus large protein and HBV DNA showed a downward trend, and the two have a good consistency, the results also showed that the reduction of hepatitis B virus large protein is later than the reduction of HBVDNA, in the treatment In patients with significant response, HBV large protein is about 5 months later than HBV DNA, and may vary in time from different individuals. At the same time, patients with longer treatment time had significantly lower levels of hepatitis B virus large protein in patients with shorter duration of treatment, and there was a significant difference between the two. Researchers believe that this large protein is later than the phenomenon of DNA in the blood, which is important for observing the therapeutic effect. The reason is that anti-nucleoside drugs are currently the main antiviral drugs for the treatment of chronic hepatitis B. The decline in serum HBV DNA copy number is currently the main indicator for evaluating its efficacy, but clinical application shows that the HBV DNA copy number in blood drops and turns. Yin can not be used as a marker for monitoring the antiviral effect of hepatitis B and the endpoint of withdrawal, and a considerable proportion of patients rebound after antiviral therapy. Because hepatitis B virus large protein is related to viral replication due to its special preS structure, the researchers believe that the use of HBV DNA markers alone in the monitoring of therapeutic effects is not enough. It should increase transactivation of hepatitis B virus replication and have direct effects on hepatocytes. Detection of toxic hepatitis B virus large protein. ——Midi Medical Network
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