Drinking alcohol and coffee together will increase the damage of alcohol to the human body. This is because alcohol can damage all cells of the body. After drinking, alcohol is quickly absorbed by the digestive system and enters the blood circulation system, affecting the functions of organs such as gastrointestinal, heart, liver, kidney, brain, and endocrine, causing disorder in the metabolism of the human body. The most severely affected is the brain. Because it can make the cerebral cortex hyperactive or paralyzed. The main component of coffee is caffeine, suitable for drinking, excitement, refreshing and stomachic effect, and excess can cause poisoning. People who drink coffee for a long period of time, once stopped drinking, will cause the brain to be highly inhibited, with symptoms such as a drop in blood pressure and severe headaches. Some may even experience mental disorders such as moodiness, irritability, and depression.