Folic acid acts as a coenzyme in the synthesis of nucleic acids and proteins in the body. Without it, the nucleic acid cannot be synthesized and the cells will not be able to divide. The tissue cells will not grow. Pigs have many physiological characteristics. The characteristics of metabolism and utilization of folic acid are their physiological characteristics. First, the characteristics of folic acid metabolism 1. Pig's high rate of folic acid metabolism in the pig's plasma contains a large number of folate binding protein. The active folic acid synthesized by the liver can accumulate in the blood and is bound by the binding protein and becomes very stable. This encapsulated folic acid enters the cell with the blood and can also be provided immediately to the tissue as needed. Frequent animals often do not have much folate binding protein. The amount of folic acid binding protein in plasma of humans, mice, dogs, sheep, horses, and cattle was only 0.33%-1% of pigs. 2. It is difficult for pigs to use synthetic folic acid pigs to efficiently distribute active folic acid synthesized by the liver into cells. However, pigs cannot use synthetic folic acid, and it is necessary to use active folic acid for supplementation. Japan has now developed raw materials for pigs that use cheap and active folic acid, which may be used as feed additives. 3. Low folic acid reductase activity in pigs Synthetic folic acid, once present in cells, is first reduced to active folic acid under the action of folate reductase and enters the folic acid metabolism cycle. Takahisa et al., of the College of Veterinary Medicine, Tokyo University of Agriculture and Engineering, added active folic acid to pigs for feeding tests. The active folic acid availability decreased with the coexistence of folic acid in the digestive tract of pigs. Since both active folic acid and synthetic folic acid utilize a common absorption channel in the digestive tract, the synthesis of folic acid may prevent the absorption of active folic acid. 4. Pigs can not use synthetic folic acid, and the utilization of folic acid is low to feed pigs with synthetic folic acid. Although the concentration of active folic acid in plasma does not increase, but the total folic acid concentration increases, therefore, for the synthesis of folic acid It was absorbed, but it was not utilized by pig. Xiao Jiu Jiang Rongyi, who fed adult pigs with folic acid-free diets for more than 2 months, fed pigs with active folate preparations under hunger-feeding conditions. The amount of absorbed folic acid was measured at this time. The experimental results showed that the active folic acid was added. The utilization decreases with the increase in the amount of synthetic folic acid. As early as the 1997 annual meeting of the Japan Society of Pig Breeding, Koichi Jiu Jung first thought that the addition of synthetic folic acid to pig feed was not necessary for reconsideration. Second, the promotion of growth of piglets by active folic acid and the improvement of sow estrus rate. Koichi Koichi et al. Conducted a series of investigations on the suitability of commercial bacteria containing high concentrations of active folic acid in pigs. So far, a large number of pig farms have been confirmed by tests such as the increase in the number of pigs born, the number of weaned pigs, the weight of weaned piglets, and the shortening of time from sow weaning to re-estrus. In terms of piglet development and sow estrus improvement trials, they divided 60 sows (2-5 times) into two groups of 30 animals. The test group was fed from the usual amount of A-PG starting from the week before delivery to the estrus day after weaning. The test results showed that the growth promotion of piglets and improvement of sow estrus rate after the addition of A-PG in the whole process from before and after delivery, to the period of lactation, and then to re-estrus after weaning can be seen, and it can be seen that the re-estrus time after weaning is shortened Effect. There are many pig-rearing institutions around the world that have studied the effect of A-PG on reproductive efficiency and efficacy of sows. However, the effect of improvement in the rate of estrus has not been studied as yet. Therefore, the results of this experiment are positive and constructive. The significance. Xiao Jiu Jiang Rong has already confirmed several clinical trials that active folic acid has the effect of shortening the re-estrus time after weaning.
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