Release date: 2018-03-28
Shanghai scholars have achieved the first human lung regeneration in history, which also indicates that the regeneration of the human internal organs is gradually moving from the laboratory to the clinic.
Zuo Wei is in the introduction of the paper. Xu Weishe
Tongji University announced on the 8th that the professor of Tongji University Medical College took the lead in the international use of adult lung stem cell transplantation, and successfully achieved lung regeneration in the clinic.
In the study, dozens of stem cells taken from the patient's bronchial brush were transplanted into the lesions of the patient's lungs after tens of millions of times in vitro. After 3 to 6 months, these stem cells gradually formed new alveolar and bronchial tubes. The structure, and thus the repair, replaces the damaged tissue.
Recently, this major breakthrough in the field of stem cell regenerative medicine was published in the latest issue of Protein & Cell.
The research results of Zuowei's team are published in the latest issue of Protein&Cell in the form of a cover article. Xu Weishe
In the accompanying articles distributed during the same period, Professor JunWu of the Texas Medical Center and Professor Liu Guanghui of the Institute of Biophysics of the Chinese Academy of Sciences commented on this achievement: “The basic and clinical data presented by the Institute are of great value and show regenerative medicine. Exciting prospects."
At present, various lung diseases in China are in a high incidence state. Once the lung tissue is damaged and fibrosis occurs, the condition often continues to develop and cannot be reversed. However, traditional drugs can only slow the progression of their fibrosis.
Stem cells are a special type of cell that has the ability to repair tissue regeneration. Since the beginning of this century, with stem cell research becoming a hotspot in global medical research, lung stem cell transplantation has become the last hope of these patients.
Researchers are in the lab. Xu Weishe
During his work abroad, Zuo invented the technology of lung stem cell expansion and transplantation. The related results were published in the journal Nature, which has aroused widespread concern in the academic community. In 2015, Zuo joined Tongji University as a national youth “Thousand Talents Program†expert and “Changjiang Scholar†and continued his previous research.
The lungs stem cells cultured by the research team were first transplanted into the damaged lungs of mice. Three weeks after transplantation, it was found that the fibrotic lesions in the lungs of mice were replaced by newborn human alveoli, and the lungs of the mice became very healthy. , can almost be called "rebirth."
The researchers also found that only adult stem cells from the human lung bronchus have the function of regenerating the lungs, while stem cells from other parts of the lungs do not have the function of regenerating lung tissue.
The success of a series of animal experiments has attracted the attention of respiratory and lung patients, and they are eager to apply this new lung stem cell transplantation and regeneration technology to the clinic as soon as possible. After sufficient preliminary preparation and long-term observation, the first batch of patients was enrolled in the beginning of 2016, and the first batch of patients was enrolled in the beginning of 2016. The Oriental Hospital of Tongji University and the Southwest Hospital affiliated to the PLA Military Medical University opened the world. The first clinical trial of stem cell-based lung regeneration.
Autologous lung stem cell transplantation clinical trial (swelling, transplantation for 12 months). Photo courtesy
In March 2017, Zuo was awarded the “Clinical Study of Human Autologous Bronchial Basal Cell (Lung Stem Cell) Transplantation for Interstitial Pulmonary Disease†by the team and the Oriental Hospital of Tongji University. It was approved as the National Health Planning Commission and the Food and Drug Administration. The first batch of stem cell clinical research projects.
Described in this paper are the first two patients with bronchiectasis who underwent autologous lung stem cell transplantation. The two have been transplanted for more than one and a half years from the publication of the paper. After one year of transplantation, both patients reported improvement in symptoms such as cough, cough, and wheezing.
CT imaging showed that one of the patients' bronchiectasis showed a local repair after one year. The lung function test indicated that the lung function of the transplanted stem cells did not improve after one month, and the lung function began to improve after three months. It is maintained until one year later.
Dr. Dai Xiaotian, the specific moderator of clinical research and the respiratory department of Southwest Hospital, found that the overall effect of stem cell transplantation was very successful. "In particular, we can observe the reversal of lung function in patients after treatment, which is an effect that traditional treatment methods cannot achieve."
Xu Jinfu, director of the Department of Respiratory Medicine of Shanghai Pulmonary Hospital affiliated to Tongji University, believes that many lung diseases are currently lacking effective treatment methods. The left lung regeneration technology is very magical and has good clinical prospects.
Zuo Wei told reporters that more than 80 clinical lung stem cell transplants have been carried out so far, involving different diseases such as bronchiectasis, chronic obstructive pulmonary disease and interstitial lung disease. It is planned to start the new drug declaration (IND) process for cell therapy products in 2018. .
The left team is currently conducting multi-center collaborative research with a number of stem cell filing medical institutions. Experts including the academician of the respiratory disease, Zhong Nanshan, have high hopes for the in-depth development of this project.
Zhang Jun, secretary of the Party Committee of Tongji University School of Medicine, said that "stem cells and regenerative medicine" is the most important development of Tongji medical science in recent years. The result of Zuo Wei's team is one of the important representative achievements of Tongji University in the field of stem cell and transformation research in recent years.
Tongji University also regards “transformation medical research†as a major strategy for the new round of development of Tongji Medical. It encourages the best scientists in basic research in medical schools and life sciences and technology colleges to form a “partner†with relevant clinical experts from affiliated hospitals. The "type" research team, for the major clinical diseases to jointly tackle the problem.
It is reported that in 2010, Tongji University established the Institute of Advanced Translational Medicine, and set up a translational medicine center in each affiliated hospital to refine the four major directions, one of which is the stem cell research center, which has now become the Shanghai Science and Technology Center. important parts of.
Source: China News Network
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