USP Pharmaceutical Antitumor Doxorubicin Hydrochloride for Antineoplastic

  • Model NO.: 164656-23-9
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS: 25316-40-9
  • MW: 579.98
  • Appearance: Orange to Dark Red Powder
  • Standard: USP
  • Delivery Time: 5-7 Days
  • Transport Package: Accoding to Every Customers′ Requirements
  • Origin: China
  • Powder: Yes
  • Certification: GMP, HSE, ISO 9001, USP, BP
  • State: Solid
  • Synonym: Adriamycin HCl
  • Mf: C27h30clno11
  • Einecs: 246-818-3
  • Melting Point: 216′c (DEC.)(Lit.)
  • Usage: Used as an Antineoplastic
  • Trademark: Saichuang
  • Specification: qualified
  • HS Code: 3001200010
USP Pharmaceutical Antitumor Doxorubicin Hydrochloride for Antineoplastic

 
Quick Detail:
Product Name
Doxorubicin Hydrochloride 
 
Synonym
Adriacin; Adriblastina;Adriblastina Hydrochloride; Adriamycin Hcl;Adriamycin Hydrochloride
 
CAS NO
25316-40-9
 
Molecular Formula
C27H30ClNO11
 
Molecular Weight
579.98
 
EINECS
246-818-3
 
Assay
99%
 
Standard
USP
 
Appearance
orange to dark red powder
 
Melting Point
216 °C (dec.)(lit.)
 
Boiling Point
810.3 °C at 760 mmHg
 
Flash Point
443.8 °C
 
Packing
1kg/tin/foil bag
 
Usage
Used as an antineoplastic. Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.
 
Storage
In cool & dry place, keep away from strong light.
 
Shelf Life
2 years when properly stored.
 


Description:

Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.

It is a drug used in cancer chemotherapy. It is an anthracycline antibiotic, closely related to the natural product daunomycin, and like all anthracyclines, it works by intercalating DNA, with the most serious adverse effect being life-threatening heart damage. It is commonly used in the treatment of a wide range of cancers, including hematological malignancies, many types of carcinoma, and soft tissue sarcomas.

Application:
 
1 Hodgkin's disease and lymphosarcoma, reticulum cell sarcoma. 
2 Undifferentiated small cell and non-small cell lung cancer, breast cancer. 
3 Acute lymphoblastic and myeloid leukemia. 
4 Osteosarcoma and soft tissue sarcoma. 
5 Ovarian cancer, testicular cancer, bladder cancer . Wilms cancer, prostate cancer, thyroid cancer, neuroblastoma cancer, esophageal cancer, stomach cancer, liver cancer, cervical cancer and head and neck cancer. Multiple myeloma, pancreatic cancer, endometrial cancer and brain tumors can also be applied. 

Uses:

1.Used as an antineoplastic

2.Strong fluorescent dye intercalating into DNA. Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA. Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent.

3.Doxorubicin hydrochloride (adriamycin hydrochloride) is an antitumour agent that has been formulated as a salt to achieve higher water solubility. While the salt shares the same pharmacological properties as doxorubicin free base, its greater water solubility may offer advantages in some in vitro applications. 

Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems the free base and salt may behave differently.

4.Doxorubicin is an anthracycline antitumor antibiotic that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks. By intercalating within DNA, doxorubicin inhibits nucleic acid synthesis and induces apoptosis by inducing the accumulation of the p53 tumor suppressor protein.


Our Advantage:
 
1.High quality with competitive price
A. Standard: Enterprise Standard
B. All Purity≥ 98%
C.We are manufacturer and can provide high quality products with factory price.
 
2.Fast and safe delivery
A. Parcel can be sent out in 24 hours after payment. Tracking number available
B. Customs pass rate ≥ 98%
C. Secure and discreet shipment. Various transportation methods for your choice.
D. We have our own agent/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring. We have done with this business for many years, the delivery is experienced.
 
3. Good after-sales service
Tell the package update ASAP, and will try to solve when customer encountered various problems.Keep in touch with you at any time.



 
 
 
 

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